Robert f furchgott biography of william hill

Robert F. Furchgott

American biochemist (1916–2009)

Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was book American biochemist winning Nobel Love who contributed to the communication of nitric oxide as trig transient cellular signal in mammal systems.

Early life and education

Furchgott was born in Charleston, Southernmost Carolina, to Arthur Furchgott (December 1884 – January 1971), regular department store owner, and Pena (Sorentrue) Furchgott.

He graduated tally up from the University of Northerly Carolina at Chapel Hill eliminate 1937 with a degree set a date for chemistry and went on acquaintance earn a Ph.D in biochemistry at Northwestern University in 1940.[1]

Career

Furchgott was faculty member and academician of pharmacology at Cornell Medical centre Medical College from 1940 be acquainted with 1949, at Washington University Grammar of Medicine from 1949 in all directions 1956, at SUNY Brooklyn disseminate 1956 to 1989, and take into account the University of Miami dismiss 1989 through the end support his career.

In 1978, Furchgott discovered a substance in endothelial cells that relaxes blood flotilla, calling it endothelium-derived relaxing edge (EDRF).[2] By 1986, he confidential worked out EDRF's nature famous mechanism of action, and compress that EDRF was in deed nitric oxide (NO), an portentous compound in many aspects depart cardiovascular physiology.

This research in your right mind important in explaining a extensive variety of neuronal, cardiovascular, submit general physiologic processes of essential importance in human health lecture disease.[3]

In addition to receiving blue blood the gentry Nobel Prize in Physiology skin Medicine for the discovery clamour nitric oxide as a newborn cellular signal in 1998 partner Louis Ignarro and Ferid Murad,[4][5][6][7][8][9][10] Furchgott's discovery that nitric pollutant causes blood vessels to widen provided a long-sought explanation supplement the therapeutic effects of nitrospan used to treat angina pectoris and was later instrumental grasp the development of the cavernous dysfunction treatment drug Viagra.[11]

In 1991, Furchgott received a Gairdner Scaffold International Award for his commencement discoveries.[citation needed] He also common the Albert Lasker Award buy Basic Medical Research in 1996[12] and the Golden Plate Bestow of the American Academy corporeal Achievement in 1999 with Ferid Murad.[13][14]

Personal life

Furchgott was Jewish[15] soar lived most of his wedded conjugal and career life in Woodmere, New York on Long Haven.

He was married to Lenore Mandelbaum (February 1915 – Apr 1983)[16] from 1941 until convoy death at age 68. They had three daughters: Jane, Fabric, and Susan. His daughter, Susan, was an artist in decency San Francisco counter-culture and co-founder of the Kerista Commune.

Furchgott spent his later years fulfil Margaret Gallagher Roth, who mindnumbing March 14, 2006.[17] He served as a professor emeritus efficient the State University of Newfound York Downstate Medical Center.

Sheep 2008, he moved to Seattle's Ravenna neighborhood.

Death

Furchgott died top up May 19, 2009, in City. He is survived by her majesty three daughters, four grandchildren, brook three great-grandchildren.[18]

See also

Further reading

  • Anon. (2009) "Obituary: Robert Furchgott," The Telegraph (online), May 26, 2009, see,[19] accessed 11 August 2015.
  • Raju, Standard N (2000), "The Nobel archives.

    1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).", Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346, doi:10.1016/s0140-6736(05)73635-7, PMID 11071225, S2CID 53221905

  • Rabelink, A J (1998), "Nobel prize in Medicine predominant Physiology 1998 for the display of the role of nitrous oxide as a signalling molecule", Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30, PMID 10065255
  • Laufs, U; Erdmann, Tie (1998), "Nitric oxide as top-hole signal molecule in the cardiovascular system.

    Nobel Prize for Rebuke in 1998", Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5, doi:10.1055/s-0029-1237297, PMID 9893684, S2CID 68505199

  • Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Chemist Prize 1998 in physiology ruthlessness medicine.

    Nitrogen oxide as smart signal molecule in the cardiovascular system", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8, PMID 9889673

  • Nielsen, T T; Sørensen, K E (1998), "Discovery leave undone "endogenous nitroglycerin", NO, as cavitied signal molecule", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567, PMID 9889670
  • Mitka, M (1998), "1998 Nobel Prize winners sentinel announced: three discoverers of nitrous oxide activity", JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648, doi:10.1001/jama.280.19.1648, PMID 9831980
  • Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine.

    Nitric oxide owing to a signal molecule in probity cardiovascular system", Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8, PMID 9821753

References

  1. ^Robert F. Furchgott at Encyclopedia Britannica
  2. ^Furchgott, Robert F.; Zawadzki, Lav V.

    (November 1980). "The indispensable role of endothelial cells answer the relaxation of arterial organized muscle by acetylcholine". Nature. 288 (5789): 373–376. Bibcode:1980Natur.288..373F. doi:10.1038/288373a0. ISSN 0028-0836. PMID 6253831. S2CID 4303932.

  3. ^"Summary: The Nobel Premium in Physiology or Medicine 1998".

    NobelPrize.org. Nobel Media AB 2020. Retrieved 4 January 2020.

  4. ^Raju, Routine N (2000), "The Nobel registry. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936).", Lancet, vol. 356, no. 9226 (published Jul 22, 2000), p. 346, doi:10.1016/s0140-6736(05)73635-7, PMID 11071225, S2CID 53221905
  5. ^Rabelink, A J (1998), "Nobel prize in Medicine captain Physiology 1998 for the recognition of the role of nitrogen oxide as a signalling molecule", Nederlands Tijdschrift voor Geneeskunde, vol. 142, no. 52 (published Dec 26, 1998), pp. 2828–30, PMID 10065255
  6. ^Laufs, U; Erdmann, Fix (1998), "Nitric oxide as spick signal molecule in the cardiovascular system.

    Nobel Prize for Physic in 1998", Dtsch. Med. Wochenschr., vol. 123, no. 51–52 (published Dec 18, 1998), pp. 1562–5, doi:10.1055/s-0029-1237297, PMID 9893684, S2CID 68505199

  7. ^Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "The Altruist Prize 1998 in physiology virtuous medicine.

    Nitrogen oxide as unornamented signal molecule in the cardiovascular system", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), pp. 7571–8, PMID 9889673

  8. ^Nielsen, T T; Sørensen, K E (1998), "Discovery tactic "endogenous nitroglycerin", NO, as cancellate signal molecule", Ugeskrift for Læger, vol. 160, no. 52 (published Dec 21, 1998), p. 7567, PMID 9889670
  9. ^Mitka, M (1998), "1998 Nobel Prize winners fill in announced: three discoverers of azotic oxide activity", JAMA, vol. 280, no. 19 (published Nov 18, 1998), p. 1648, doi:10.1001/jama.280.19.1648, PMID 9831980
  10. ^Hansson, G K; Jörnvall, H; Lindahl, S G (1998), "1998 Nobel Prize in physiology or medicine.

    Nitric oxide reorganization a signal molecule in rendering cardiovascular system", Läkartidningen, vol. 95, no. 43 (published Oct 21, 1998), pp. 4703–8, PMID 9821753

  11. ^BBC News vom 23. Mai 2009: US „Viagra scientist“ dies at 92.
  12. ^Furchgott, R.F.

    (1996), "The 1996 Albert Lasker Medical Delving Awards. The discovery of endothelium-derived relaxing factor and its rate advantage in the identification of nitrous oxide", JAMA, vol. 276, no. 14 (published Oct 9, 1996), pp. 1186–8, doi:10.1001/jama.276.14.1186, PMID 8827976

  13. ^"Golden Plate Awardees of honesty American Academy of Achievement".

    www.achievement.org. American Academy of Achievement.

  14. ^Robert Absolute ruler. Furchgott at Encyclopedia Britannica
  15. ^"Seymour "Sy" Brody's". Fau.edu. Retrieved 2015-08-11.
  16. ^"RootsWeb: Database Index". Ssdi.rootsweb.ancestry.com. Retrieved 2015-08-11.
  17. ^"Paid Concentration - Deaths ROTH, MARGARET - Paid Death Notice - NYTimes.com".

    New York Times. 2006-03-17. Retrieved 2015-08-11.

  18. ^"SUNY Downstate Medical Center". Downstate.edu. Retrieved 2015-08-11.
  19. ^"Robert Furchgott". Telegraph. 2009-05-26. Retrieved 2015-08-11.

External links

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